Model Intestinal Microflora In Computer Simulation: A Simulation and Modelling Package for Host-Microflora Interactions
نویسنده
چکیده
The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this increase in observing power. This is in part due to the complexity of the system, and to the lack of simulation environments in which to test what the ecological effect of a hypothetical mechanism of interaction would be, before resorting to laboratory experiments. The MIMICS project attempts to address this through the development of a cellular automaton for simulation of the intestinal microflora. In this paper the design and evaluation of this simulator are discussed. Keywords— Computer simulation, microbial ecology, parallel computing, human intestines, intestinal microflora.
منابع مشابه
In Silico Modeling of the Human Intestinal Microflora
The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this development. This is in part due to the complexity of the system, and to the lack of simulation environments in which to test what the ecologi...
متن کاملIntestinal microflora and homeostasis of the mucosal immune response: implications for probiotic bacteria?
The intestinal microflora can be considered a postnatally acquired organ that is composed of a large diversity of bacteria that perform important functions for the host and can be modulated by environmental factors, such as nutrition. Specific components of the intestinal microflora, including lactobacilli and bifidobacteria, have been associated with beneficial effects on the host, such as pro...
متن کاملShort communication:Effect of oral consumption of Aloe vera gel on intestinal microflora and liver tissue of rainbow trout
متن کامل
The effect of adding pomegranate seed extract to fat-containing diets on nutrients digestibility, intestinal microflora and growth performance of broilers
The present study was aimed at studying the effects of inclusion of pomegranate seed extract to fat-containing diets on nutrients digestibility, intestinal microflora and performance of broilers. A total of 320 one-day-old broiler chicks (Ross 308) were selected in a 2 × 2 × 2 factorial experiment in a completely randomized design with 4 replicates o...
متن کاملGrowth Performance, Carcass Characteristics and Intestinal Microflora of Broiler Chickens Fed Diets Containing Carum copticum Essential Oil
We evaluated the effects of dietary Carum copticum essential oil (CCEO) on growth performance, carcass characteristics and intestinal microflora of broiler chickens. A total of 240 Cobb broiler chickens were allocated to five dietary treatments, each with four replicates of 12 birds. Dietary treatments were prepared by formulating a corn-soybean meal-based diet free of antibiotics (Control) and...
متن کامل